Table 4. Meta-analysis for recessive inheritance model of each SNP.
| SNP | Gene | Model | Study | OR (95%CI) | Weight (%) | Cochran’s Q | I2 | Τ2 | pooled OR (95%CI) | p-value |
|---|---|---|---|---|---|---|---|---|---|---|
| rs11079454 | BRIP1 | Fixed | Ma XD et al (2013) | 0.79 (0.58–1.08) | 52.88 | 0.99 | 0.00 | 0.00 | 0.79 (0.63–0.99) | 0.04 |
| Wang SS et al (2010) | 0.81 (0.46–1.41) | 15.92 | ||||||||
| Ma XD et al (2013) | 0.77 (0.52–1.15) | 31.20 | ||||||||
| rs2048718 | BRIP1 | Fixed | Wang SS et al (2010) | 0.88 (0.63–1.23) | 58.06 | 0.32 | 13.1 | 0.01 | 1.05 (0.78–1.42) | 0.75 |
| Ma XD et al (2013) | 1.35 (0.78–2.34) | 26.34 | ||||||||
| Ma XD et al (2013) | 1.34 (0.65–2.80) | 15.60 | ||||||||
| rs6504074 | BRIP1 | Fixed | Ma XD et al (2013) | 0.99 (0.60–1.64) | 26.87 | 0.82 | 0.00 | 0.00 | 1.08 (0.83–1.40) | 0.59 |
| Wang SS et al (2010) | 1.15 (0.82–1.63) | 58.03 | ||||||||
| Ma XD et al (2013) | 0.95 (0.48–1.86) | 15.09 | ||||||||
| rs231775 | CTLA-4 | Random | Xioing YH et al (2014) | 0.51 (0.33–0.79) | 21.48 | 0.04 | 62.8 | 0.05 | 0.82 (0.62–1.10) | 0.18 |
| Gokhale P et al (2013) | 0.79 (0.45–1.38) | 16.18 | ||||||||
| Wang SS et al (2010) | 1.10 (0.81–1.50) | 28.11 | ||||||||
| Hu L et al (2010) | 0.89 (0.72–1.10) | 34.23 | ||||||||
| rs5742909 | CTLA-4 | Fixed | Gokhale P et al (2013) | excluded | 0.19 | 41.2 | 0.54 | 2.47 (0.55–11.12) | 0.24 | |
| Ivansson EL et al (2010) | 1.42 (0.44–4.63) | 65.49 | ||||||||
| Xioing YH et al (2014) | 7.02 (0.84–58.58) | 34.51 | ||||||||
| rs1800872 | IL-10 | Random | Wang SS et al (2010) | 1.24 (0.79–1.95) | 32.77 | <0.01 | 83.3 | 0.24 | 0.87 (0.47–1.61) | 0.66 |
| Singhal P et al (2014) | 0.46 (0.30–0.72) | 32.98 | ||||||||
| Shekari M et al (2012) | 1.15 (0.78–1.72) | 34.25 | ||||||||
| rs1800896 | IL-10 | Random | Wang SS et al (2010) | 0.80 (0.43–1.48) | 25.11 | <0.01 | 87.00 | 0.61 | 1.51 (0.66–3.45) | 0.33 |
| Wang Q et al (2011) | 1.26 (0.68–2.36) | 25.05 | ||||||||
| Barbisan G et al (2012) | 1.15 (0.50–2.62) | 22.62 | ||||||||
| Singhal P et al (2014) | 3.99 (2.65–6.01) | 27.23 | ||||||||
| rs16944 | IL-1B | Random | Wang SS et al (2010) | 1.10 (0.78–1.54) | 33.43 | 0.06 | 59.9 | 0.08 | 1.09 (0.74–1.59) | 0.67 |
| Al-Tahhan MA et al (2011) | 0.34 (0.12–0.98) | 10.14 | ||||||||
| Qian N et al (2010) | 1.09 (0.78–1.53) | 33.50 | ||||||||
| Zidi S et al (2014) | 1.77 (1.01–3.11) | 22.92 | ||||||||
| rs1801133 | MTHFR | Fixed | Kohaar I et al (2010) | 1.13 (0.30–4.27) | 8.93 | 0.58 | 0.00 | 0.00 | 0.97 (0.65–1.44) | 0.87 |
| Tong SY et al (2011) | 1.08 (0.67–1.74) | 68.49 | ||||||||
| Mostowska A et al (2011) | 0.65 (0.28–1.50) | 22.59 | ||||||||
| rs11515 | p16 | Fixed | Thakur N et al (2012) | 0.20 (0.01–4.14) | 7.43 | 0.41 | 0.00 | 0.00 | 1.29 (0.56–2.95) | 0.55 |
| Vargas-Torres et al (2014) | 1.82 (0.53–6.25) | 47.51 | ||||||||
| Wang SS et al (2010) | 1.24 (0.37–4.15) | 45.06 | ||||||||
| rs3088440 | p16 | Random | Wang SS et al (2010) | 0.82 (0.52–1.29) | 44.24 | 0.04 | 68.8 | 0.47 | 1.43 (0.56–3.67) | 0.45 |
| Vargas-Torres et al (2014) | 1.30 (0.34–4.90) | 24.82 | ||||||||
| Thakur N et al (2012) | 3.46 (1.24–9.71) | 30.95 | ||||||||
| rs1801270 | p21 | Fixed | Wang N et al (2013) | 0.62 (0.45–0.87) | 59.37 | 0.47 | 0.00 | 0.00 | 0.69 (0.54–0.89) | <0.01 |
| Wang SS et al (2010) | 0.90 (0.55–1.48) | 21.41 | ||||||||
| Jiang P et al (2010) | 0.66 (0.37–1.18) | 19.21 | ||||||||
| rs1042522 | p53 | Random | Jiang P et al (2010) | 2.01 (1.14–3.57) | 16.45 | <0.01 | 91.9 | 0.74 | 1.04 (0.50–2.14) | 0.92 |
| Ferreira da Silva I et al (2010) | 0.72 (0.42–1.26) | 16.56 | ||||||||
| El khair MM et al (2010) | 0.92 (0.45–1.87) | 15.59 | ||||||||
| Yang SD et al (2014) | 1.62 (1.00–2.61) | 16.99 | ||||||||
| Ye F et al (2010) | 0.30 (0.22–0.43) | 17.63 | ||||||||
| Jiang P et al (2010) | 1.98 (1.18–3.32) | 16.78 | ||||||||
| rs1136410 | PARP-1 | Random | Roszak A et al (2013) | 1.54 (0.80–2.97) | 28.48 | <0.01 | 83.3 | 0.26 | 1.61 (0.85–3.04) | 0.14 |
| Ye F et al (2012) | 2.57 (1.85–3.57) | 36.89 | ||||||||
| Wang SS et al (2010) | 1.01 (0.66–1.54) | 34.63 | ||||||||
| rs352140 | TLR9 | Random | Roszak A et al (2012) | 1.19 (0.88–1.62) | 38.88 | 0.06 | 59.6 | 0.12 | 1.39 (0.88–2.19) | 0.16 |
| Lai ZZ et al (2013) | 7.07 (0.87–57.54) | 4.35 | ||||||||
| Zidi S et al (2014) | 2.02 (1.21–3.40) | 29.45 | ||||||||
| Pandey S et al (2011) | 0.88 (0.50–1.56) | 27.32 | ||||||||
| rs1800629 | TNF | Random | Barbisan G et al (2012) | 10.34 (0.53–201.98) | 7.99 | 0.03 | 67.5 | 0.51 | 1.74 (0.69–4.41) | 0.24 |
| Ivansson EL et al (2010) | 0.75 (0.44–1.26) | 38.66 | ||||||||
| Roszak A et al (2015) | 2.28 (1.09–4.78) | 34.42 | ||||||||
| Sousa H. et al (2014) | 2.81 (0.56–14.06) | 18.93 | ||||||||
| rs25487 | XRCC1 | Random | Wang SS et al (2010) | 0.60 (0.37–0.96) | 39.74 | <0.01 | 79.2 | 0.39 | 0.98 (0.43–2.24) | 0.96 |
| Roszak A et al (2011) | 1.74 (1.07–2.83) | 39.56 | ||||||||
| Settheetham-Ishida W et al (2011) | 0.84 (0.22–3.23) | 20.70 |