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. 2016 Jul 14;11(7):e0155888. doi: 10.1371/journal.pone.0155888

Fig 1. Circulating extracellular RNA (exRNA) after partial hepatectomy.

Fig 1

(A). Serum was collected from mice at the indicated time points after partial hepatectomy, and exRNA was isolated. Total exRNA was quantitated using NanoDrop. An increase in circulating total exRNA was seen at six hours after partial hepatectomy. Bars represent average concentration of total exRNA yield from 4 separate samples. (B and C) RNA seq was performed on serum exRNA, and analysis of the serum exRNA was performed using the Maverix pipeline. Differentially-expressed extracellular non-coding RNA were determined across samples. (B) Non-coding RNA that are mapped include miRNA, tRNA, snoRNAs, antisense transcripts and repeat elements. (C). Bar chart representing the most highly differentially-expressed circulating EV non-coding RNA within selected classes six hours after partial hepatectomy. These differentially-expressed extracellular non-coding RNA are candidate biomarkers of a liver regenerative response.