Table 2. Functional gene annotation of putative exRNA targets.

Gene Ontology Biological Process	Fold Enrichment	False discovery rate	P-Value (x10-3)	Bonferroni (x10-3)
Extracellular structure organization	5.0	0.1	0.065	0.092
Embryonic organ morphogenesis	4.2	0.97	0.59	0.58
Extracellular matrix organization	5.4	1.1	0.68	0.64
Embryonic organ development	3.1	4.6	2.8	0.99
Collagen fibril organization	13.0	5.4	3.3	0.99

Predicted targets of circulating exRNA that are significantly altered after partial hepatectomy were identified using the mirror algorithm, and functional annotation with gene ontology was performed to identify the most common biological processes modulated by these targets using DAVID.