Table 2. Clinical characteristics related to disease severity with respect to the rs4819554 genotype distribution.

	Cohort 1 (n = 180)			Cohort 2 (n = 419)			Both cohorts (n = 599)
	AA genotype n = 104	Gx genotype n = 76	p	AA genotype n = 240	Gx genotype n = 179	p	AA genotype n = 344	Gx genotype n = 255	p
BASDAI, mean (SD)	3 (2.2)	3.3 (2.2)	NS	3.9 (2.5)	4.4 (2.3)	<0.05	3.7 (2.7)	4.1 (2.6)	<0.05
BASDAI adjusted by duration of disease evolution, mean (SD)	0.19 (0.29)	0.23 (0.35)	NS	0.18 (0.12)	0.22 (0.13)	<0.05	0.19 (0.24)	0.22 (0.29)	NS
BASFI, mean (SD)	3.1 (2.6)	4.2 (2.7)	<0.01	3.7 (2.7)	4.3 (2.8)	<0.05	3.7 (2.7)	4.2 (2.8)	<0.05
BASFI adjusted by duration of disease evolution, mean (SD)	0.15 (0.13)	0.21 (0.14)	<0.01	0.15 (0.12)	0.19 (0.13)	<0.01	0.15 (1.4)	0.19 (1.4)	<0.01

Note: Gx genotype includes GG and GA genotypes