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. Author manuscript; available in PMC: 2016 Jul 14.
Published in final edited form as: Behav Neurosci. 2015 Oct;129(5):599–610. doi: 10.1037/bne0000093

Figure 8.

Figure 8

Two competing hypotheses of intact cognitive performance in old age: Neural Maintenance versus Neural Compensation. In the scenario presented here, compared to young, aged-impaired animals with perirhinal (PER) dysfunction would have reduced functional connectivity between this structure and adjacent regions. The Neural Maintenance view predicts that functional connectivity across the hippocampal (HPC)-PER-prefrontal cortical (PFC) network is conserved in aged-unimpaired rats, showing the same patterns of interregion communication as young animals. In contrast, the Neural Compensation view predicts that HPC-PER-PFC functional connectivity would change in the face of PER dysfunction to maintain behavior. See the online article for the color version of this figure.