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Manhattan plot for the single-variant association results. A total of 34,976 variants with minor allele frequency (MAF) ≥1.0% were tested for single-variant associations. The significance threshold across the exome was set to p<2.1×10−6 (red line). Suggestive associations were discovered on two variants in the TCTE1 gene region at 6p21.1: rs2297336 (p = 3.7 ×10−6) and rs324146 (p = 1.4 ×10−5).
