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. 2016 Apr 5;100(2):381–389. doi: 10.1189/jlb.3A1015-474R

Figure 5. Model of DC-FB crosstalk governing IL-23-dependent Th17 responses after irradiation.

Figure 5.

(A) TLR activation of DCs in monoculture elicits secretion of IL-1β, -6, and -23, which prime Th17 responses. (B) The addition of FB to DC provides an important feedback loop that serves to enhance IL-23 secretion and thus, augments Th17 responses. (C) Irradiation of DC monocultures selectively inhibits IL-23 secretion. (D) However, the presence of FBs ensures that irradiated DCs continue to secrete sufficient IL-23 to generate Th17 responses. Importantly, the irradiation of FBs does not hinder their reinforcement of IL-23 responses.