Skip to main content
. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Pharm Res. 2016 May 10;33(8):1959–1971. doi: 10.1007/s11095-016-1932-2

Figure 1.

Figure 1

Live optical imaging of SIM/SIM-mPEG micelle’s distribution in mice with a closed right femur fracture. IRDye® 800CW-labeled SIM/SIM-mPEG was given via tail vein injection on 7th day post-surgeries. Mice were imaged prior and each day after the administration of the labeled micelle for the following 7 days (n=3). (A) According to the sequence of images taken, the fractured femurs demonstrate more intense and longer lasting NIR signals than the intact side. (B) During a semi-quantitative analysis, the NIRF signal intensity from the labeled SIM/SIM-mPEG was measured from a consistent region of interest (yellow circle) at the fracture (FX) site and intact control (Con) site for all the mice. (C) Compared to the intact leg, the fractured side demonstrated more intense NIRF signal in the femoral region. The signal intensity differences between the two sides are statistically significant (t-test, P < 0.05).