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βH inhibition activities for the di-benzamides 15a–15p and tri-benzamide 20.
| Compound | R1 substituent | βH inhibition IC50 (μM) |
|---|---|---|
| 15a | Nitro | 4.3 ± 0.1 |
| 15b | 4.7 ± 0.7 | |
| 15c | 7.0 ± 0.2 | |
|
| ||
| 15d | Cyano | 6.34 ± 0.09 |
| 15e | 4.4 ± 0.2 | |
|
| ||
| 15f | Methyl | 8 ± 1 |
| 15g | >1000 | |
|
| ||
| 15h | tert-Butyl | 13.3 ± 0.7 |
| 15i | 6.8 ± 0.1 | |
| 15j | >1000 | |
|
| ||
| 15k | H | 507 ± 33 |
| 15l | >1000 | |
|
| ||
| 15m | Methoxy | 22 ± 1 |
| 15n | > 1000 | |
|
| ||
| 15o | H (X = N) | 260 ± 7 |
| 15p | >1000 | |
|
| ||
| 20 | N/A | 21 ± 1 |
|
| ||
| CQ | N/A | 31.5 ± 0.5 |
