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. Author manuscript; available in PMC: 2017 Jul 14.
Published in final edited form as: J Med Chem. 2016 Jun 24;59(13):6512–6530. doi: 10.1021/acs.jmedchem.6b00719

Table 6.

K1 and CHO data for selected benzamides

Compound K1 parasite IC50, μM (RI)a CHO IC50, μM (SI)b
15a 2.86 ± 0.08 (4.1) >275 (>393)
15i 1.7 ± 0.4 (2.8) 185 (308)
CQ 0.222 (27.8) N/A
a

Resistance index, IC50 (K1)/IC50 (NF54);

b

Selectivity index, IC50 (CHO)/IC50 (NF54)