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Kinetic solubility in various media and metabolic stability in human, rat and mouse liver microsomes.
| Compound | Kinetic solubility (μM) pH 2 /6.5 / FaSSIF | Liver microsomal species | Degradation half-life (min) | In vitro clearance (μL/min/mg protein) | Hepatic extraction (EH) |
|---|---|---|---|---|---|
| 15a | 199.7 / <5 / 13 | Human | >150 | <11.6 | <0.42 |
| Rat | >150 | <11.6 | <0.30 | ||
| Mouse | >150 | <11.6 | <0.33 | ||
|
| |||||
| 15i | 197.2 / 92.7/ 153.6 | Human | 141.9 | 14.1 | 0.4 |
| Rat | 93.2 | 33.5 | 0.4 | ||
| Mouse | 52.4 | 130.3 | 0.6 | ||
