Table 4.

Race/ethnic-specific association results for KCNK3 SNP rs2586886 for aldosterone levels in MESA.

Stratum	Group	Effect allele frequency	N	Beta	SE	P-value
All	White	0.37	683	0.068	0.059	0.252
	African American	0.41	311	0.206	0.081	0.011
	Hispanic	0.30	415	0.158	0.081	0.052
	Chinese	0.75	211	0.205	0.103	0.047
	Meta-analysis			0.138	0.038	3.0E-04
No hypertension medication	White	0.38	382	−0.102	0.071	0.150
	African American	0.35	118	0.033	0.120	0.783
	Hispanic	0.31	245	0.127	0.097	0.192
	Chinese	0.71	137	0.177	0.113	0.119
	Meta-analysis			0.020	0.047	0.664
Hypertension medication	White	0.40	286	0.263	0.099	0.008
	African American	0.42	174	0.210	0.113	0.065
	Hispanic	0.31	160	0.251	0.144	0.082
	Chinese	0.77	74	0.306	0.210	0.150
	Meta-analysis			0.248	0.063	8.4E-05

Genetic association results for square-root transformed aldosterone levels (in ng/dL) reported under an additive 1 d.f. SNP dosage model for rs2586886 effect allele C (other allele T). Analysis of aldosterone conducted with adjustment for sex, age, study site and race/ethnic specific PCs of ancestry.