Table 3. Association of Success of Decongestion and Change in Serum Bicarbonate by Trial.

Trial/Decongestion Status	Baseline	72 or 96 hours	Change	p-value*
All Trials				0.85
Successful Decongestion† (N=83)
Bicarbonate (mEq/L), Mean (SD)	26.4 (4.3)	28.7 (3.6)	2.3 (4.0)
Unsuccessful Decongestion (N=580)
Bicarbonate (mEq/L), Mean (SD)	27.9 (4.1)	29.6 (4.2)	1.6 (3.7)
DOSE-AHF				0.26
Successful Decongestion (N=33)
Bicarbonate (mEq/L), Mean (SD)	26.1 (4.9)	28.9 (3.7)	2.8 (4.3)
Unsuccessful Decongestion (N=187)
Bicarbonate (mEq/L), Mean (SD)	28.4 (4.0)	29.5 (3.9)	1.1 (3.3)
ROSE-AHF				0.79
Successful Decongestion (N=39)
Bicarbonate (mEq/L), Mean (SD)	26.4 (4.1)	28.8 (3.7)	2.4 (3.3)
Unsuccessful Decongestion (N=263)
Bicarbonate (mEq/L), Mean (SD)	27.4 (4.0)	29.6 (4.2)	2.2 (3.5)
CARRESS-HF				0.48
Successful Decongestion (N=11)
Bicarbonate (mEq/L), Mean (SD)	26.9 (2.6)	27.8 (3.7)	0.9 (5.2)
Unsuccessful Decongestion (N=130)
Bicarbonate (mEq/L), Mean (SD)	28.2 (4.5)	29.4 (4.9)	1.2 (4.3)

^*p values obtained from linear regression model. Models were adjusting for baseline serum bicarbonate (and trial when all trials were combined)

^†Successful decongestion is defined as JVP < 8cm, no orthopnea, and trace or no peripheral edema