Table 5.
Pathway terms significantly enriched with differential methylation in BPA-exposed mice and/or with hepatic tumors
| Name | Comparison | #Genes | P-Value | FDR | Direction |
|---|---|---|---|---|---|
| Acute Myocardial Infarction | Tumor vs. No tumor | 14 | 6.24E-04 | 0.093603 | up |
| Selenocompound metabolism | Low BPA vs. Control | 13 | 1.28E-05 | 0.00258 | up |
| African trypanosomiasis | Low BPA vs. Control | 19 | 9.75E-04 | 0.098459 | down |
| Role of Erk5 in Neuronal Survival | High BPA vs. Control | 10 | 1.76E-04 | 0.026328 | up |
| Histamine H2 receptor mediated signaling pathway | High BPA vs. Control | 12 | 0.002505 | 0.039036 | up |
| Beta3 adrenergic receptor signaling pathway | High BPA vs. Control | 15 | 0.002672 | 0.039036 | up |
| 5HT4 type receptor mediated signaling pathway | High BPA vs. Control | 16 | 0.002882 | 0.039036 | up |
| Endogenous cannabinoid signaling | High BPA vs. Control | 13 | 0.002974 | 0.039036 | up |
| Cortocotropin releasing factor receptor signaling pathway | High BPA vs. Control | 17 | 0.002982 | 0.039036 | up |
| Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction | High BPA vs. Control | 19 | 0.003299 | 0.039036 | up |
| 5HT1 type receptor mediated signaling pathway | High BPA vs. Control | 20 | 0.004139 | 0.039036 | up |
| Beta1 adrenergic receptor signaling pathway | High BPA vs. Control | 23 | 0.004662 | 0.039036 | up |
| Beta2 adrenergic receptor signaling pathway | High BPA vs. Control | 24 | 0.005096 | 0.039036 | up |
| GABA-B receptor II signaling | High BPA vs. Control | 18 | 0.005347 | 0.039036 | up |
| Metabotropic glutamate receptor group II pathway | High BPA vs. Control | 27 | 0.008168 | 0.047157 | up |
| Histamine H1 receptor mediated signaling pathway | High BPA vs. Control | 27 | 0.008371 | 0.047157 | up |
| Oxytocin receptor mediated signaling pathway | High BPA vs. Control | 35 | 0.009135 | 0.047157 | up |
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | High BPA vs. Control | 34 | 0.010031 | 0.047157 | up |
| Metabotropic glutamate receptor group III pathway | High BPA vs. Control | 39 | 0.010058 | 0.047157 | up |
| PI3 kinase pathway | High BPA vs. Control | 30 | 0.010336 | 0.047157 | up |
| 5HT2 type receptor mediated signaling pathway | High BPA vs. Control | 37 | 0.011884 | 0.04919 | up |
| Thyrotropin-releasing hormone receptor signaling pathway | High BPA vs. Control | 36 | 0.012129 | 0.04919 | up |
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway signaling pathway | High BPA vs. Control | 34 | 0.014209 | 0.054593 | up |
| Metabotropic glutamate receptor group III pathway | High BPA vs. Control | 39 | 0.010058 | 0.047157 | up |
| PI3 kinase pathway | High BPA vs. Control | 30 | 0.010336 | 0.047157 | up |
| 5HT2 type receptor mediated signaling pathway | High BPA vs. Control | 37 | 0.011884 | 0.04919 | up |
| Thyrotropin-releasing hormone receptor signaling pathway | High BPA vs. Control | 36 | 0.012129 | 0.04919 | up |
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | High BPA vs. Control | 34 | 0.014209 | 0.054593 | up |