Table 3. Neoplasia Risk Ratios (If Reported).
| Study | Neoplasia categories | Analysis type | Cases, mean (SD) | Controls, mean (SD) | OR or HRa (95% CI) | P-value |
|---|---|---|---|---|---|---|
| Rutter et al. (2004)1 | Any neoplasia | Univariate | 2.38 (0.56) (n=68) | 2.05 (0.41) (n=136) | 5.13 (2.36-11.14)b | <0.001 |
| Multivariate | - | - | 4.69 (2.10-10.48)b | <0.001 | ||
| CRC only | Univariate and multivariatec | 2.09 (0.44) | 2.54 (0.60) | 6.33 (1.24-32.33) | 0.030 | |
| Gupta et al. (2007)2 | Any neoplasia | Univariate | (n=65) | (n=353) | 1.4 (0.90-2.30)a | NS |
| Advanced neoplasiad | Univariate | (n=15) | (n=403) | IS-meana: 3.0 (1.40-6.30) |
<0.050 | |
| IS-bine: 3.4 (1.10-10.40) | ||||||
| IS-maxf: 2.2 (1.20-4.20) | ||||||
| Multivariate | (n=15) | (n=403) | IS-meana: 3.8 (1.70-8.60) 5.4 (1.70-17.00)g |
<0.050 | ||
| Rubin et al. (2013)4 | Any neoplasia | Univariate | 2.00 (0.89) (n=32) | 1.55 (0.68) (n=139) | Mean-score: 2.56 (1.45-4.54) |
0.001 |
| Any neoplasia | Maximum-score: 1.41 (1.03-1.91) |
0.030 | ||||
| Multivariate | - | - | Mean-score: 3.68 (1.69-7.98) |
0.001 | ||
| Dysplasia | Univariate | 2.07 (0.97) (n=44) | 1.52 (0.71) (n=104) | 2.54 (1.35-4.78) | 0.004 | |
| Cancer | Univariate | 1.79 (0.51) (n=15) | 1.62 (0.60) (n=37) | 2.64 (0.69-10.2) | NS |
Outcomes only reported for significant values, unless no outcome was significant for a specific neoplasia outcome.
aHazard ratio of IS-mean (For 1-unit increase the cumulative mean histologic inflammation score, there was a X fold increase for neoplasia).
bOdds ratio of colorectal neoplasia if 1-unit increase in histological score.
cSame effect size and significance, for both univariate and multivariate model, because histologic inflammation was the only variable in model.
dAdvanced neoplasia: high-grade dysplasia and cancer.
eBinary inflammation score: 1 if IS-mean ≥1.
fMaximum inflammation score over time.
gControlled for 1 or more colonoscopies per year.
HR, hazard ratio; CRC, colorectal cancer.