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. 2016 Jul 16;4(7):155–164. doi: 10.12998/wjcc.v4.i7.155

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

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Classification of resolvins. Resolvins are biosynthesized from ω-3 polyunsaturated fatty acids (PUFA) by specific enzymes including lipoxygenase (LOX). Resolvin E (RvE) is endogenously produced from eicosapentaenoic acid (EPA) during endothelial cell-leukocyte interaction. RvE1 and RvE2 are biosynthesized through two different pathways via cytochrome P450-driven oxygenation of EPA or via aspirin-acetylated cyclooxygenase 2 (COX-2). RvE3 is generated via the 12/15-LOX pathway. In addition, resolvin D (RvD) is biosynthesized from docosahexaenoic acid (DHA) via 15/5-LOX within vascular endothelial cells. To date, six members of this family has been identified RvD1-6. Also, RvD is also biosynthesized via aspirin-acetylated COX-2, and we call aspirin triggered RvD (AT-RvD).