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. 2016 Jun 30;7(1):11–18. doi: 10.1016/j.stemcr.2016.06.002

Figure 2.

Figure 2

Spontaneous Deletion of Different Floxed Genes in Hematopoietic Cells from Mx1-Cre Mice Expressing Flt-3ITD

(A) Evaluation of Hif-1α deletion in colonies derived from fetal liver (E14.5) (n = 4) or BM (12-week-old mice) (n = 3) cells from Flt-3ITD/+; Hif-1αflox/flox; Mx1-Cre embryos/mice.

(B) Evaluation of Phd2 deletion in colonies from BM (12-week-old mice) cells (n = 2) from Flt-3ITD/+; Phd2flox/flox; Mx1-Cre mice.

(C and D) Flow cytometry analysis of dendritic cells (pDCs [CD45+CD19−CD3−CD11b−B220+ CD11clow/int] and cDCs [CD45+CD19−CD3−CD11b−B220−CD11c+]) (C) in BM and spleen (D) from FLT-3ITD/+ and WT animals (n = 6). Plots show mean ± SEM. ∗∗p < 0.01, ∗∗∗p < 0.001. See also Figure S3.