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. 2016 Jun 30;7(1):11–18. doi: 10.1016/j.stemcr.2016.06.002

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© 2016 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Alterations in Phenotype of BM Stem and Progenitor Subsets after pIpC Injections

(A) Col1a1-tetO-H2B-mCherry mice fed with doxycycline-containing food were injected with pIpC and analyzed 1 (n = 4), 3 (n = 4), 8 (n = 3), and 24 days (n = 3) after the last injection. Representative histograms show H2B-mCherry label retention in HSPCs at the indicated time points after pIpC injection.

(B and C) Frequencies of (B) phenotypic myeloid progenitors and (C) LSK HSPC subsets 24 or 72 hr following one pIpC injection.

(D) SCA1 expression in phenotypically defined HSCs and GMLPs. In red, mean fluorescent intensity (MFI) values of SCA1 and, in blue, average percentage of SCA1⁺ cells (blue gating). Plots represent mean ± SD. Ctrl, control; HSC, hematopoietic stem cell; GMLP, granulocyte/macrophage lymphoid progenitors; preGM, pre-granulocyte/macrophage progenitors; MkP, megakaryocyte progenitor; preMegE, pre-megakaryocyte–erythrocyte progenitors; preCFU-E, pre-colony-forming units-erythrocytes; CFU-E, colony-forming units-erythrocytes; MPP, multipotent progenitor; LSK, Lin⁻SCA1⁺cKIT⁺. See also Figure S4.