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. 2016 Jul 15;10:178. doi: 10.3389/fncel.2016.00178

Figure 3.

Figure 3

Activity-dependent increase in microglial density after 7 days of naris occlusion. (A) Microglia in (i) open and (ii) occluded OBs. Scale bars: 200 μm. (B) Higher microglial density in occluded OB than open (*p = 0.042) or control (**p = 0.009) OBs; no difference between open and control OBs (p = 0.76) [one-way ANOVA with Tukey's test; p = 0.009, F(2, 13) = 6.914]. (C) Higher microglial density in glomerular (GL; *p = 0.048, t = 2.83), external plexiform (EPL; **p = 0.009, t = 4.78), and granule cell (GCL; *p = 0.011, t = 4.53; paired t-tests) layers of occluded OBs. B,C: n = 6 pooled pairs of OBs from 6 control mice and 5 pairs of open and occluded OBs from 5 naris-occluded mice. (D) No difference in number of microglia between open and occluded OBs in total (p = 0.97, t = 0.03) or for the GL (p = 0.79, t = 0.28), EPL (p = 0.28, t = 1.24), or GCL (p = 0.91, t = 0.11; paired t-tests). (E) Decreased total OB area (*p = 0.011, *p = 0.030, *p = 0.027, **p = 0.003, t = 4.54), GL area (p = 0.030, t = 3.31), EPL area (p = 0.027, t = 3.39) and GCL area (p = 0.003, t = 6.59; paired t-tests) in occluded vs. open OBs. (D,E): n = 5 pairs of open and occluded OBs from 5 naris-occluded mice.