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. 2016 Jul 15;10:178. doi: 10.3389/fncel.2016.00178

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Copyright © 2016 Grier, Belluscio and Cheetham.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglial-neuronal interactions are activity-dependent. (A,B) 3D reconstructions showing microglia (A) contacting multiple DA neurons or (B) wrapping a DA neuron. (C) Similar percentage of DA neurons contacted by microglia in occluded and open OBs (p = 0.22, t = 1.56, paired t-test). (D) Greater microglial wrapping of DA neurons in occluded OBs (^*p = 0.017, t = 4.78, paired t-test). (C,D): n = 4 pooled pairs of control OBs from 4 control mice and 4 pairs of open and occluded OBs from 4 naris-occluded mice.