Figure 1.

Schematic illustration of brain multiplex functional network construction. (A) We measure the brain activity with a set of 264 ROIs (here, we only draw five ROIs, for simplicity), and estimate the coherence spectrum of signals between any pair of ROIs. (B) Averaged coherence values are calculated in 12 frequency bands (here we only show four bands, for simplicity), to quantify the strength of frequency-specific functional connectivity. The statistical significance of each connection is calculated (see Methods) and connections with Z-score smaller than 3 are discarded. (C) The remaining connections are used to build adjacency matrices, weighted by Z-scores, that constitute the layers of the multiplex functional network once interconnected. (D) Resulting single-layer and multiplex networks obtained from this procedure.