Figure 10.

Effect of the anticonvulsant drugs valproate and phenytoin on spontaneous seizure expression during the incubation/recording period in C57BL/6J mice exposed to flurothyl. C57BL/6J mice were exposed to the 8 d induction paradigm (10% flurothyl) following the implantation of electrodes and monitored for spontaneous seizures for the duration of the incubation period. Following the eighth seizure (induction trial 8), mice were administered valproate (125 or 250 mg/kg), phenytoin (20 mg/kg), or vehicle (0.9% normal saline) twice daily. Vehicle-injected control mice, the group treated with a valproate dose of 125 mg/kg, and phenytoin-treated mice expressed spontaneous seizures. In contrast, mice receiving 250 mg/kg valproate did not develop spontaneous seizures (*p < 0.03 vs control). Plot denotes mean ± SEM.