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. 2016 Jun 27;5(6):e238. doi: 10.1038/oncsis.2016.38

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Copyright © 2016 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Bifidobactreia suppress colonic inflammation and carcinogenesis in Ffar2^−/− mice. (a) Ffar2^−/− mice fed with FP diet and 1 month later were challenged with AOM/DSS and B. infantis as shown. B. infantis was gavaged everyday (2 × 10⁸ cfu/mouse) as indicated from day of AOM injection till the completion of DSS treatment. (b) Relative abundance of Bifidobacterium in mice gavaged with B. infantis or saline as in a. Shown is the weight loss (c) during and after DSS challenge. (d) A representative photograph of H&E stained cross-section of colons of mice 4 days after cessation of DSS treatment. (e) Histopathological score (inflammation+epithelial damage) of colons. (f) Polyp burden in colons of mice treated as described in a at experimental endpoint. A representative of two experiments is shown (n=4 mice). *P<0.05, **P<0.01, ***P<0.0001.