Table 2. Univariate and multivariate analyses of potential prognostic factors associated with overall survival of HCC patients.
| Variables | Cases |
Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Gender (male/female) | 190/31 | 0.701 (0.404–1.216) | 0.207 | ||
| Age (⩽50/>50 years) | 107/114 | 2.475 (1.588–3.858) | <0.001 | 2.621 (1.661–4.135) | <0.001 |
| Serum HBsAg (negative/positive) | 104/117 | 1.022 (0.690–1.514) | 0.913 | ||
| Serum AFP (⩽20/>20 ng/ml) | 102/118 | 0.897 (0.606–1.327) | 0.587 | ||
| Tumor size (⩽5/>5 cm) | 109/112 | 1.288 (0.868–1.911) | 0.209 | ||
| Tumor number (single/multiple) | 169/52 | 1.849 (1.168–2.929) | 0.009 | 2.346 (0.313–17.575) | 0.407 |
| Tumor differentiation (I–II/III–IV) | 173/48 | 7.228 (4.450–11.742) | <0.001 | 1.988 (1.090–3.623) | 0.025 |
| Cirrhosis (absent/present) | 101/120 | 1.069 (0.720–1.589) | 0.740 | ||
| TNM stage (I–II/III–IV) | 171/50 | 10.935 (6.645–17.995) | <0.001 | 7.483 (3.978–14.074) | <0.001 |
| Tumor microsatellite (absent/present) | 167/54 | 1.809 (1.137–2.877) | 0.012 | 0.399 (0.051–3.133) | 0.382 |
| Portal vein tumor thrombus (absent/present) | 197/24 | 5.518 (3.189–9.549) | <0.001 | 0.811 (0.408–1.613) | 0.551 |
| Recurrence (absent/present) | 198/23 | 5.222 (2.608–10.454) | <0.001 | 1.011 (0.484–2.109) | 0.977 |
| ANCCA expression (−/+/++) | 79/119/23 | 6.955 (4.604–10.508) | <0.001 | 4.507 (2.697–7.534) | <0.001 |
| MiR-372 expression (low/high) | 23/23 | 0.015 (0.000–10.927) | 0.212 | ||
CI, confidence interval; HCC, hepatocellular carcinoma; HR, hazard ratio.
The P-value was calculated by Cox proportional hazards model.