Figure 2.

Survivin is highly expressed in high-grade chondrosarcoma. (a) Immunohistochemical analysis of survivin in conventional chondrosarcoma showing higher cytoplasmic expression in grade II and III central chondrosarcoma compared with ACTs. Also higher expression of nuclear survivin is observed in grade III chondrosarcomas compared with ACTs. Each dot represents one patient, and mean value with standard deviation is shown for each group. (b) High cytoplasmic survivin expression in a grade III chondrosarcoma. (c) Immunohistochemical analysis of nuclear and cytoplasmic survivin in dedifferentiated, clear cell and mesenchymal chondrosarcoma. Nuclear survivin is highly expressed in nuclei of the well-differentiated part of dedifferentiated chondrosarcoma and clear cell chondrosarcoma compared with the cytoplasmic part. Each dot represents one patient, and mean value with standard deviation is shown for each group. (d) High nuclear survivin expression in dedifferentiated chondrosarcoma (dedifferentiated part).