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. 2016 May 9;5(5):e222. doi: 10.1038/oncsis.2016.33

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Copyright © 2016 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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P53 is highly expressed in high-grade conventional chondrosarcoma and correlated with nuclear survivin in grade III chondrosarcoma. (a) Immunohistochemical analysis of p53 expression in conventional chondrosarcoma. Grade II and III chondrosarcomas show significantly higher expression compared with grade I chondrosarcoma (P<0.0001). Each dot represents one patient, and mean value with standard deviation is shown for each group. (b) High nuclear p53 expression in a high-grade chondrosarcoma. (c) Low nuclear p53 expression in a high-grade chondrosarcoma. (d) Correlation between nuclear survivin and p53 overexpression in conventional chondrosarcoma. P53 is considered as overexpressed when it reached a sum score of 4 (indicated by +). Grade I chondrosarcomas did not show p53 overexpression. In grade II chondrosarcoma, higher nuclear survivin was seen in p53 overexpressing chondrosarcomas, as well as in grade III chondrosarcoma (P<0.01) compared with low p53 expressing tumors. Each dot represents one patient, and mean value with standard deviation is shown for each group.