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Overexpression of HIF-1α reversed miR-186-induced inhibitory effects on PD-L1, PFKP and HK2 protein abundance and PFK and HK2 activities. (a) Overexpression of HIF-1α partly reversed miR-186-induced inhibition on PD-L1, PFKP and HK2 protein expression levels. (b) Introduction of HIF-1α partly reversed miR-186-induced inhibition on PFK and HK2 activities. *P<0.05, **P<0.01.
