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. 2016 Jun 27;173(15):2352–2368. doi: 10.1111/bph.13513

Figure 1.

Figure 1

Age‐related decrease in the hepatic NAD+ pool and impaired NAD+ salvage biosynthesis pathway in mice and humans. (A) NAD+ level in liver tissues obtained from adult (4‐month‐old), middle‐aged (12‐month‐old) and old (20‐month‐old) mice. *P < 0.05. n = 8 for each group. (B) Immunoblotting analysis of the protein levels of NAMPT, IDO, NADS and NMNAT in liver tissues from adult, middle‐aged and old mice. *P < 0.05. n = 6 for each group. (C) NAD+ level in liver tissues obtained by hepatectomy from patients. *P < 0.05. n = 6 for each group. (D) Immunoblotting analysis of the protein levels of NAMPT, IDO, NADS and NMNAT in liver tissues obtained by hepatectomy from patients. *P < 0.05. n = 6 for each group. (E) Immunohistochemistry analysis of the protein levels of NAMPT, IDO, NADS and NMNAT in liver tissues obtained by hepatectomy from patients. *P < 0.05. n = 6 for each group.