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. 2016 Jun 27;173(15):2352–2368. doi: 10.1111/bph.13513

Figure 4.

Figure 4

NAD+ pool deficiency promotes steatohepatitis in diet‐induced NAFLD model. (A) Lipid profile in livers of WT and DN‐NAMPT mice with NAFLD. *P < 0.05. n = 8 for each group. (B) HE staining in livers of WT and DN‐NAMPT mice with NAFLD. (C) Oil Red O staining in livers of WT and DN‐NAMPT mice with NAFLD. *P < 0.05. n = 8 for each group. (D) Apoptosis in livers of WT and DN‐NAMPT mice with NAFLD was determined by TUNEL staining. *P < 0.05. n = 8 for each group. TNF‐α protein (E) and mRNA (F) expression in livers of WT and DN‐NAMPT mice with NAFLD. *P < 0.05. n = 8 for each group. (G) Activation of NLRP‐3 inflammasome pathway and production of IL‐1β and IL‐18 in livers of WT and DN‐NAMPT mice with NAFLD. *P < 0.05. n = 4 for each group. ASC, apoptosis‐associated speck‐like protein.