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. 2016 Jun 27;173(15):2352–2368. doi: 10.1111/bph.13513

Figure 5.

Figure 5

NAD+ pool deficiency increases fibrosis and insulin resistance in diet‐induced NAFLD model. (A) The mRNA levels of pro‐fibrosis genes in livers of WT and DN‐NAMPT mice with NAFLD. *P < 0.05. n = 8 for each group. Protein levels of α‐SMA in livers of WT and DN‐NAMPT mice with NAFLD were detected by immunoblotting (B) and immunohistochemistry (C). *P < 0.05. n = 8 for each group. (D) Masson's staining in livers of WT and DN‐NAMPT mice with NAFLD. *P < 0.05. n = 8 for each group. (E) Phosphorylation of Akt in liver tissues of WT and DN‐NAMPT mice with NAFLD before and after bolus injection of insulin. *P < 0.05. n = 8 for each group. (F) DAG levels in liver tissues of WT and DN‐NAMPT mice. *P < 0.05. n = 8 for each group. (G) Protein level of PKCε in liver tissues of WT and DN‐NAMPT mice. *P < 0.05. n = 8 for each group.