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. 2016 Jun 21;173(15):2419–2433. doi: 10.1111/bph.13519

Figure 2.

Figure 2

Cinnamaldehyde (CA)‐induced vasodilatation is dependent on CGRP. Blood flow was measured in response to topical cinnamaldehyde (10% CA) and vehicle (10% DMSO in ethanol) in the anaesthetized mouse ear. Results recorded over 30 min and analysed as AUC. Group mean data for CA‐induced vasodilatation in WT mice pretreated with (A) a combination of CGRP receptor antagonist CGRP8‐37 (400 nmol•kg−1) and substance P NK1 receptor antagonist SR140333 (480 nmol•kg−1, n = 5) or control (0.01% BSA in saline, n = 5), (B) SR140333 alone or control (saline, n = 5) and (C) CGRP8‐37 alone or control (0.01% BSA in saline, n = 5). (D) CA‐induced vasodilatation in α‐CGRP WT and KO mice (n = 5). Effects of pretreatment of (E) ATP‐sensitive K+ channels (KATP) blocker glibenclamide (20 mg•kg−1, n = 5). All errors indicate SEM. *P < 0.05 versus vehicle‐treated ears of WT mice; #P < 0.05 versus CA‐treated ears of WT mice (2‐way ANOVA and Bonferroni post hoc test).