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. 2016 Jun 21;173(15):2369–2389. doi: 10.1111/bph.13514

Figure 1.

Figure 1

Dietary capsaicin prevents obesity in WT but not in TRPV1−/− mice and counters the suppressive effect of HFD on TRPV1 expression. (A) Representative images of WT and TRPV1−/− mice fed with respective dietary regimen (n = 40). (B) Representative Western blots showing the expression of TRPV1 channel protein in HEK293 WT, HEK‐TRPV1 cells, EF and SCF isolated from NCD‐fed WT and TRPV1−/− mice at 38 weeks of age. (C) and (D) The average mRNA levels ± SEM of trpv1 normalized to NCD in EF and SCF. 18s ribosomal RNA was used as control. (E) TRPV1 expression in EF and SCF pads of NCD‐fed and HFD (± CAP)‐fed WT mice and TRPV1−/− conditions. (F) Ratios of band intensity ± SEM of TRPV1 to GAPDH (loading control); data shown are means ± SEM. ** P < 0.05, significantly different as indicated.