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. 2016 Jul 12;4(13):e12855. doi: 10.14814/phy2.12855

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© 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Differential effects of atropine on the time course of AHP decay following presynpatic nerve stimulation in control versus long‐term SCS. In both panels, AHP decay surface areas were estimated from the AHP following the last AP of each stimulus train. (A) The time course of AHP decay was faster at low presynaptic nerve stimulation frequencies in preparations from long‐term SCS (n = 47) compared to control (n = 24) (*P < 0.05, ^#marginally significant, P = 0.06). (B). In a subgroup of preparations that was exposed to atropine (control, n = 19; SCS, n = 6), atropine (10 μmol/L) induced a prolongation of the time course of AHP decay across all frequencies in neurones from control but not among those from long‐term SCS. Data are mean ± SD.