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. 2016 Jan 21;2(1):e00060. doi: 10.1016/j.heliyon.2015.e00060

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Dose-dependent cytotoxicity of the isatin derivatives 1-5 is maintained in doxorubicin resistant MES-SA (MES-SA/Dx5) subline. Cells were incubated with increasing concentrations of either (A) 5,7-dibromoisatin (1), (B) 5,7-dibromo-N-(p-hydroxymethylbenzyl)isatin (2), (C) 5,7-dibromo-N-(p-phenylbenzyl)isatin (3), (D) 5,7-dibromo-N-(p-cinnamyl)isatin (4), (E) 5,7-dibromo-N-(napthalen-1-ylmethyl)isatin (5) or (F) colchicine (as a control). The relative sensitivity of the MES-SA (black) and MES-SA/Dx5 (red) cell lines to the drugs was determined by MTS assay after 48 h incubation. Values are the mean (± SEM) of triplicates.