Table 1. Characteristics of the two independent study populations.
| Initial study Population | Second study Population | |||||
|---|---|---|---|---|---|---|
| Cases(n = 200) | Controls(n = 200) | Pvalue | Cases(n = 810) | Controls(n = 825) | Pvalue | |
| Sex (males/females) | 112/88 | 106/94 | 0.547 | 416/394 | 428/397 | 0.833 |
| Age (mean ± SD, years) | 57.2 ± 7.2 | 55.9 ± 7.0 | 0.090 | 57.7 ± 8.6 | 55.3 ± 7.2 | 0.243 |
| Total cholesterol (mmol/L) | 5.18 ± 1.09 | 4.54 ± 1.34 | 0.000* | 5.22 ± 1.17 | 4.62 ± 1.29 | 0.016* |
| Total triglyceride (mmol/L) | 1.89 ± 1.03 | 1.41 ± 1.01 | 0.000* | 1.94 ± 1.31 | 1.35 ± 1.13 | 0.017* |
| Hypertension, (n, %) | 80 (40.0) | 26 (13.0) | 0.000* | 469 (57.9) | 98 (11.9) | 0.000* |
| Diabetes, (n, %) | 32 (16.0) | 9 (4.5) | 0.000* | 134 (16.5) | 26 (3.2) | 0.000* |
| Smokers, (n, %) | 33 (16.5) | 20 (10.0) | 0.055 | 112 (13.8) | 64 (7.8) | 0.000* |
| Alcohol, (n, %) | 34 (17.0) | 28 (14.0) | 0.407 | 133 (16.4) | 118 (14.3) | 0.235 |
*P < 0.004 denotes statistical significance in the initial cohort.
*P < 0.025 denotes statistical significance in the second cohort.