Table 2. The genotype and allelic distribution of 18 SNPs in the promoter region of ALOX5AP in IS and control subjects.
| SNP | Allele | Cases (n/%) | Controls (n/%) | P value | OR (95%CI) |
|---|---|---|---|---|---|
| 1785G>A | G | 400 | 400 | ||
| A | 0 | 0 | — | — | |
| 946A>G | A | 400 | 400 | ||
| G | 0 | 0 | — | — | |
| 581_582lnsA | D | 400 | 400 | ||
| I | 0 | 0 | — | — | |
| 519G>A | G | 400 | 400 | ||
| A | 0 | 0 | — | — | |
| 290G>A | G | 400 | 400 | ||
| A | 0 | 0 | — | — | |
| 190G>A | G | 400 | 400 | ||
| A | 0 | 0 | — | — | |
| rs34536374 | C | 331 (82.75) | 316 (79) | ||
| T | 69 (17.25) | 84 (21) | 0.178 | 0.784 (0.551–1.117) | |
| rs34344566 | G | 74 (18.5) | 88 (22) | ||
| A | 326 (81.5) | 312 (78) | 0.218 | 1.243 (0.879–1.756) | |
| rs9578194 | G | 322 (80.5) | 306 (76.5) | ||
| A | 78 (19.5) | 94 (23.5) | 0.169 | 0.789 (0.562–1.106) | |
| rs34352240 | T | 70 (17.5) | 88 (22) | ||
| C | 330 (82.5) | 312 (78) | 0.110 | 1.330 (0.937–1.887) | |
| rs34404999 | A | 62 (15.5) | 80 (20) | ||
| C | 338 (84.5) | 320 (80) | 0.096 | 1.363 (0.946–1.964) | |
| rs55950839 | T | 327 (81.75) | 311 (77.75) | ||
| A | 73 (18.25) | 89 (22.25) | 0.159 | 0.780 (0.552–1.103) | |
| rs55780307 | A | 340 (85) | 325 (81.25) | ||
| G | 60 (15) | 75 (18.75) | 0.157 | 0.765 (0.527–1.109) | |
| rs59227506 | T | 330 (82.5) | 319 (79.75) | ||
| C | 70 (17.5) | 81 (20.25) | 0.320 | 0.835 (0.586–1.191) | |
| rs12560847 | C | 180 (45) | 204 (51) | ||
| T | 220 (55) | 196 (49) | 0.089 | 1.272 (0.963–1.680) | |
| rs9578195 | G | 332 (83) | 315 (78.75) | ||
| A | 68 (17) | 85 (21.25) | 0.126 | 0.759 (0.533–1.082) | |
| rs61947373 | G | 231 (57.75) | 253 (63.25) | ||
| A | 169 (42.25) | 147 (36.75) | 0.112 | 1.259 (0.948–1.673) | |
| rs17222919 | T | 322 (80.5) | 288 (72) | ||
| G | 78 (19.5) | 112 (28) | 0.005* | 0.623 (0.448–0.866) |
P value and OR (95% CI) were adjusted for confounding factors such as age, gender, hypertension, diabetes, smoking, drinking, TC and TG. Adjusted P value (P < 0.004) indicates statistical significance.