Table 2.
Cox Proportional Hazard Models Estimating the Association Between the Estimated Rate of Change in DNAm Markers of Interest and Mortality After 9-Year Follow-Up (n = 499, events = 79) Ordered by the Magnitude of the Hazard Ratio (HR)
| Marker | Chr | Position | Rate of Change (SD) | HR (95% CI) | Gene* |
|---|---|---|---|---|---|
| cg14575484 | 2 | 217557616 | 0.0002 (0.0017) | 0.60 (0.45, 0.78) | IGFBP5 |
| cg18120323 | 1 | 1978732 | 0.0008 (0.0053) | 1.67(1.34, 2.10) | PRKCZ |
| cg03402235 | 15 | 42749336 | −0.0004 (0.0030) | 1.66 (1.29, 2.15) | ZNF106 |
| cg16197857 | 18 | 75402282 | −0.00003 (0.0017) | 0.60 (0.47, 0.77) | |
| cg27635330 | 20 | 57020935 | 0.0001 (0.0019) | 0.61 (0.49, 0.77) | VAPB |
| cg16781880 | 16 | 58329007 | −0.0003 (0.0019) | 0.61 (0.48, 0.79) | PRSS54 |
| cg00292432 | 12 | 3393872 | −0.0001 (0.0028) | 1.62 (1.27, 2.06) | TSPAN9 |
| cg03623394 | 4 | 1005876 | 0.0002 (0.0023) | 0.62 (0.50, 0.77) | IDUA, FGFRL1 |
| cg03576411 | 14 | 99172002 | −0.0001 (0.0032) | 1.61 (1.25, 2.05) | C14orf177 |
| cg21158502 | 5 | 74348187 | 0.0004 (0.0033) | 1.60 (1.28, 2.01) | |
| cg24319508 | 6 | 394966 | −0.0006 (0.0030) | 1.60 (1.28, 2.00) | IRF4 |
| cg01723148 | 12 | 58021295 | 0.0002 (0.0018) | 1.60 (1.27, 2.00) | BC073932, SLC26A10, B4GALNT1 |
| cg17835356 | 8 | 41387960 | −0.0006 (0.0033) | 1.59 (1.26, 2.01) | GINS4 |
| cg07922411 | 16 | 34429609 | 0.00003 (0.0030) | 1.59 (1.25, 2.01) | |
| cg14403741 | 12 | 126465336 | −0.0001 (0.0020) | 0.63 (0.51, 0.79) | LINC00939 |
| cg19733534 | 5 | 1841548 | 0.0003 (0.0035) | 1.58 (1.26, 1.98) | |
| cg18533397 | 1 | 110186005 | −0.0001 (0.0013) | 1.58 (1.24, 2.01) | |
| cg20220255 | 12 | 95228096 | −0.0004 (0.0025) | 0.63 (0.51, 0.78) | KRT19P2 |
| cg26106417 | 4 | 3425381 | 0.00003 (0.0027) | 0.63 (0.49, 0.81) | RGS12 |
| cg11808581 | 1 | 1950725 | 0.0003 (0.0023) | 0.63 (0.50, 0.80) | AK054708, GABRD |
| cg01093854 | 10 | 70362422 | 0.0001 (0.0015) | 0.63 (0.50, 0.81) | TET1 |
| cg27601809 | 11 | 72091020 | 0.0001 (0.0023) | 1.57 (1.24, 1.99) | CLPB |
| cg22927043 | 1 | 11919699 | −0.0008 (0.0038) | 1.57 (1.27, 1.94) | NPPB |
| cg26160180 | 1 | 1822883 | −0.00004 (0.0015) | 0.64 (0.51, 0.81) | GNB1 |
| cg01514859 | 1 | 6557734 | −0.00003 (0.0011) | 1.57 (1.23, 2.00) | PLEKHG5 |
| cg12844117 | 7 | 155275418 | −0.0002 (0.0032) | 1.57 (1.25, 1.96) | |
| cg16054184 | 10 | 78944582 | 0.0002 (0.0024) | 1.56 (1.24, 1.98) | KCNMA1 |
| cg15505642 | 1 | 77836400 | 0.0001 (0.0019) | 0.64 (0.51, 0.80) | AK5 |
| cg26989202 | 8 | 99076837 | 0.0001 (0.0015) | 1.56 (1.31, 1.86) | C8orf47 |
| cg01065605 | 7 | 27702796 | 0.00004 (0.0016) | 0.64 (0.52, 0.79) | HIBADH |
| cg23608075 | 10 | 112272213 | 0.0001 (0.0015) | 0.64 (0.52, 0.80) | DUSP5 |
| cg24197330 | 19 | 47551642 | −0.0001 (0.0014) | 0.64 (0.51, 0.81) | NPAS1,TMEM160 |
| cg18741439 | 8 | 19310134 | 0.0003 (0.0026) | 1.55 (1.25, 1.92) | CSGALNACT1 |
| cg26318321 | 19 | 15446617 | 0.0000002 (0.0033) | 1.55 (1.24, 1.93) | BRD4 |
| cg23015983 | 6 | 108396139 | 0.00003 (0.0014) | 0.65 (0.51, 0.82) | OSTM1 |
| cg03967329 | 6 | 26030329 | 0.0001 (0.0030) | 1.55 (1.23, 1.95) | HIST1H3A, HIST1H4A, HIST1H4B, HIST1H3B, HIST1H2AB |
| cg24259629 | 3 | 45883796 | 0.0002 (0.0016) | 1.55 (1.23, 1.95) | LZTFL1 |
| cg11950982 | 21 | 46269126 | 0.0003 (0.0024) | 1.54 (1.20, 1.99) | PTTG1IP |
| cg19662895 | 14 | 69074455 | 0.0013 (0.0049) | 1.54 (1.25, 1.91) | RAD51B |
| cg25468681 | 1 | 9428106 | −0.0002 (0.0021) | 0.65 (0.51, 0.82) | SPSB1 |
| cg01310875 | 8 | 27938995 | −0.0002 (0.0030) | 1.54 (1.20, 1.98) | NUGGC, ELP3 |
| cg07161062 | 8 | 142204334 | −0.0004 (0.0028) | 1.54 (1.21, 1.96) | DENND3 |
| cg12379145 | 1 | 14030611 | 0.0001 (0.0017) | 1.54 (1.21, 1.95) | PRDM2 |
| cg06765172 | 22 | 36714496 | −0.0003 (0.0023) | 1.54 (1.24, 1.90) | MYH9 |
| cg02330352 | 16 | 20975912 | −0.0003 (0.0023) | 0.65 (0.52, 0.81) | DNAH3 |
| cg06281205 | 2 | 58462331 | 0.0003 (0.0019) | 1.53 (1.24, 1.90) | FANCL |
| cg11308319 | 2 | 240291426 | −0.0006 (0.0036) | 1.53 (1.23, 1.91) | HDAC4 |
| cg13665021 | 7 | 1717324 | −0.0003 (0.0031) | 0.65 (0.53, 0.81) | |
| cg08529529 | 13 | 31309799 | 0.0002 (0.0033) | 1.53 (1.23, 1.90) | ALOX5AP |
| cg23515619 | 17 | 61623700 | 0.00001 (0.0017) | 0.66 (0.52, 0.83) | KCNH6, DCAF7 |
| cg13009365 | 22 | 24093455 | −0.0001 (0.0014) | 0.66 (0.52, 0.82) | ZNF70, VPREB3 |
| cg27224642 | 2 | 39665105 | −0.0001 (0.0021) | 1.52 (1.24, 1.88) | MAP4K3, LOC728730 |
| cg02898994 | 20 | 2361440 | −0.0001 (0.0015) | 1.52 (1.19, 1.94) | TGM6 |
| cg25649038 | 6 | 6546777 | 0.0001 (0.0014) | 1.52 (1.25, 1.85) | LY86-AS1 |
| cg27257822 | 3 | 184292880 | −0.0012 (0.0033) | 1.52 (1.21, 1.91) | EPHB3 |
| cg09693464 | 7 | 41744949 | −0.0002 (0.0021) | 1.52 (1.20, 1.93) | INHBA, INHBA-AS1 |
| cg23524537 | 14 | 95036219 | −0.0001 (0.0027) | 1.52 (1.20, 1.92) | SERPINA4 |
| cg23324787 | 11 | 36619694 | −0.0004 (0.0037) | 1.51 (1.22, 1.89) | RAG1, RAG2, C11orf74 |
| cg03490711 | 3 | 187459194 | −0.0001 (0.0014) | 1.51 (1.22, 1.88) | LOC100131635, BCL6 |
| cg12484411 | 8 | 110099683 | 0.0001 (0.0025) | 1.51 (1.26, 1.81) | TRHR |
| cg10916429 | 15 | 64799784 | 0.0008 (0.0033) | 1.51 (1.22, 1.87) | ZNF609 |
| cg04373937 | 14 | 30552825 | 0.0003 (0.0022) | 0.66 (0.53, 0.82) | |
| cg16096311 | 1 | 151693261 | 0.0002 (0.0022) | 1.51 (1.20, 1.90) | CELF3, RIIAD1 |
| cg24737067 | 17 | 34432601 | −0.0002 (0.0021) | 0.66 (0.54, 0.81) | CCL4 |
| cg19174658 | 22 | 45018513 | −0.0006 (0.0021) | 0.66 (0.53, 0.83) | LINC00229 |
| cg03976645 | 7 | 16724981 | −0.0003 (0.0036) | 1.51 (1.20, 1.88) | BZW2 |
| cg02772928 | 3 | 18277949 | 0.0002 (0.0024) | 1.50 (1.22, 1.86) | LOC339862 |
| cg07457727 | 8 | 131451983 | 0.0005 (0.0026) | 1.50 (1.19, 1.90) | ASAP1 |
| cg09544380 | 10 | 27703486 | 0.0002 (0.0024) | 0.67 (0.55, 0.80) | PTCHD3 |
| cg05376185 | 1 | 47082869 | −0.0001 (0.0035) | 1.50 (1.20, 1.88) | MKNK1, MOB3C |
| cg13735018 | 6 | 158404121 | −0.0008 (0.0027) | 1.50 (1.18, 1.91) | SYNJ2 |
| cg20585841 | 8 | 102729926 | 0.0006 (0.0034) | 1.50 (1.20, 1.88) | NCALD |
| cg26078407 | 2 | 240225062 | 0.0006 (0.0034) | 1.50 (1.19, 1.89) | HDAC4, MIR4269 |
| cg07735969 | 16 | 68418473 | −0.0001 (0.0030) | 1.50 (1.21, 1.86) | SMPD3 |
| cg16989443 | 1 | 1849195 | 0.0003 (0.0019) | 0.67 (0.53, 0.84) | CALML6, TMEM52, C1orf222 |
| cg16248783 | 2 | 38304146 | 0.0002 (0.0019) | 1.50 (1.23, 1.83) | RMDN2, CYP1B1 |
Notes: CI = confidence interval. Markers were identified based upon p value < .001 and a HR > 3/2 or < 2/3.
*Gene symbols corresponding to transcripts within 10K, bold text indicates the closest gene where more than one transcript.