. 2016 Jul 15;6:29857. doi: 10.1038/srep29857

Table 1. Effects of cisplatin and indole-3-carbinol on nephrotoxicity markers in rats.

Treated groups	No of dead rats	Body weight (g)		Relative kidney weight	Blood urea nitrogen (mg/dl)	Serum creatinine (mg/dl)
Treated groups	No of dead rats	Before treatment	After treatment	Relative kidney weight	Blood urea nitrogen (mg/dl)	Serum creatinine (mg/dl)
Control	0/10	183.80 ± 8.5	228.30 ± 9.4^*	0.71 ± 0.05^b	35.75 ± 3.7^b	0.38 ± 0.12^b
Cisplatin	3/10	185.00 ± 18.7	152.60 ± 10.4^*	0.94 ± 0.20^a	174.33 ± 10.82^a	3.21 ± 0.85^a
Cisplatin/indole-3-carbinol (20 mg/kg)	0/10	174.00 ± 13.5	172.00 ± 13.7	0.57 ± 0.10^b	64.17 ± 14.50^a,b	1.42 ± 0.16^a,b
Indole-3-carbinol (20 mg/kg)	0/10	178.30 ± 12.6	195.00 ± 8.9	0.74 ± 0.10^b	34.83 ± 2.40^b	0.46 ± 0.05^b

All nephrotoxicity markers were assessed at the end of the experiment (7 days following cisplatin single dose injection).

Data are mean ± SD (n = 6–10).

a or b: Statistically significant when compared to the control or cisplatin group, respectively, P < 0.05 using ANOVA followed by Tukey-Kramer as post-hoc test.

^*Statistically significant when compared to the values obtained before treatment, P < 0.05 using unpaired t-test.