Table 2. Effects of cisplatin and indole-3-carbinol on the markers of oxidative stress and inflammation in kidney tissues of rats.
| Treated groups | GSH(μmol/g tissue) | MDA (nmol/g tissue) | SOD (U/mg protein) | NOX-1 (ng/mg protein) | IL-1β (pg/mg protein) | TNF-α (pg/mg protein) |
|---|---|---|---|---|---|---|
| Control | 2.91 ± 0.12 | 12.20 ± 0.96 | 13.02 ± 1.84 | 1.39 ± 0.35 | 13.03 ± 0.97 | 12.33 ± 1.26 |
| Cisplatin | 0.46 ± 0.11a | 86.93 ± 7.57a | 3.06 ± 0.69a | 7.24 ± 0.88a | 135.00 ± 10.34a | 95.63 ± 9.22a |
| Cisplatin/indole-3-carbinol (20 mg/kg) | 2.07 ± 0.31a,b | 18.30 ± 2.3b | 14.43 ± 1.24b | 1.76 ± 0.33b | 22.03 ± 2.75a,b | 27.02 ± 6.30a,b |
| Indole-3-carbinol (20 mg/kg) | 2.75 ± 0.26b | 12.43 ± 0.81b | 19.48 ± 1.99a,b | 0.77 ± 0.67b | 12.43 ± 0.81b | 12.18 ± 2.78b |
Data are mean ± SD (n = 6).
a or b: Statistically significant when compared to the control or cisplatin group, respectively, P < 0.05 using ANOVA followed by Tukey-Kramer as post-hoc test.
GSH: reduced glutathione; MDA: malondialdehyde; SOD: superoxide dismutase; NOX-1: NADPH oxidase-1; IL-1β: interleukin-1 beta; TNF-α: tumor necrosis factor-alpha.