Table 2. Associations between CNVs and the risk of CRC.
| Gene | No. of Cases (%) | No. of Controls. (%) | Odds Ratioa | 95% Confidence Interval | PValueb |
|---|---|---|---|---|---|
| MDM2 | |||||
| Wt | 487 (96.0) | 499 (98.4) | 1.00 | ||
| Del | 11 (2.2) | 6 (1.2) | 3.76 | 0.69, 20.61 | 0.127 |
| Amp | 9 (1.8) | 2 (0.4) | 14.37 | 1.27, 163.74 | 0.032 |
| Amp v.s. del + wt | 14.40 | 1.26, 164.81 | 0.032 | ||
| Del + amp v.s. wt | 6.35 | 1.67, 24.19 | 0.007 | ||
| SKP2 | |||||
| Wt | 452 (95.4) | 433 (91.4) | 1.00 | ||
| Del | 13 (2.7) | 25 (5.2) | 0.32 | 0.10, 1.00 | 0.050 |
| Amp | 9 (1.9) | 16 (3.4) | 0.32 | 0.10, 1.01 | 0.052 |
| Amp v.s. del + wt | 0.33 | 0.11, 1.02 | 0.055 | ||
| Del + amp v.s. wt | 0.32 | 0.14, 0.72 | 0.006 | ||
| FBXW7 | |||||
| Wt | 410 (84.9) | 400 (82.8) | 1.00 | ||
| Del | 37 (7.7) | 36 (7.5) | 1.29 | 0.61, 2.70 | 0.506 |
| Amp | 36 (4.4) | 7 (9.7) | 0.64 | 0.34, 1.23 | 0.181 |
| Amp v.s. del + wt | 0.63 | 0.33, 1.20 | 0.162 | ||
| Del + amp v.s. wt | 0.82 | 0.52, 1.42 | 0.557 | ||
| β-TRCP | |||||
| Wt | 465 (93.2) | 469 (93.8) | 1.00 | ||
| Del | 5 (1.0) | 8 (1.6) | 0.71 | 0.11, 4.41 | 0.710 |
| Amp | 29 (5.8) | 23 (4.6) | 1.59 | 0.72, 3.52 | 0.252 |
| Amp v.s. del + wt | 1.59 | 0.72, 3.51 | 0.254 | ||
| Del + amp v.s. wt | 1.40 | 0.70, 2.88 | 0.363 | ||
| NEDD4-1 | |||||
| Wt | 431 (89.0) | 448 (92.6) | 1.00 | ||
| Del | 2 (0.4) | 6 (1.2) | 0.59 | 0.08, 4.55 | 0.614 |
| Amp | 51 (10.6) | 30 (6.2) | 1.44 | 0.73, 2.87 | 0.297 |
| Amp v.s. del + wt | 1.44 | 0.72, 2.87 | 0.297 | ||
| Del + amp v.s. wt | 1.31 | 0.39, 2.51 | 0.409 | ||
aAdjusted for gender, occupation, education, and family history of cancer. bP < 0.05 in the conditional logistic regression analysis was considered statistically significant.