. 2016 Jul 15;6:29869. doi: 10.1038/srep29869

Table 3. Interactions between five gene CNVs and environmental factors on the risk of CRC.

CNV genotypes		Environmental factors		Interaction
SKP2		Roughage (g/week)
		<50	≥50
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Del + wt	1.00	0.58 (0.39, 0.88)
	Amp	0.18 (0.03, 0.98)	0.18 (0.03, 0.99)	1.72 (0.16, 18.74)	0.657
	Wt	1.00	0.62 (0.41, 0.94)
	Del + amp	0.28 (0.08, 1.00)	0.13 (0.04, 0.44)	0.74 (0.13, 4.30)	0.734
		Fruit (times/week)
		<2	≥2
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Del + wt	1.00	0.61 (0.40, 0.94)
	Amp	0.82 (0.03, 0.53)	0.70 (0.15, 3.22)	13.89 (1.20, 160.57)	0.035
	Wt	1.00	0.62 (0.34, 0.98)
	Del + amp	0.09 (0.02, 0.44)	0.33 (0.12, 0.96)	6.10 (0.92, 40.38)	0.061
		Fish (times/week)
		≤1	>1
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	0.30 (0.17, 0.52)
	Del + amp	0.09 (0.03, 0.31)	0.39 (0.08, 2.00)	13.62 (1.70, 109.36)	0.014
MDM2		Refined grains (g/day)
		≤250	>250
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	2.53 (1.59, 4.02)
	Del + amp	13.35 (2.13, 89.49)	5.44 (1.03, 28.86)	0.09 (0.00, 2.14)	0.135
		Fat meat
		No	Yes
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	2.30 (1.48, 3.57)
	Del + amp	11.25 (1.63, 77.25)	8.55 (1.22, 59.75)	0.30 (0.02, 5.09)	0.427
		Egg (/week)
		≤3	>3
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	1.60 (1.08, 2.37)
	Del + amp	9.31 (0.66, 131.06)	7.33 (1.57, 34.30)	0.49 (0.02, 10.06)	0.645
		Chinese pickled sour cabbage (times/month)
		≤2	>2
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	2.05 (1.35, 3.12)
	Del + amp	6.41 (1.16, 35.27)	27.61 (2.12, 259.81)	2.10 (0.10, 44.07)	0.633
		leftovers (times/week)^c
		≤3	>3
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	1.873 (1.234, 2.843)
	Del + amp	3.30 (0.37, 29.54)	26.67 (2.62, 271.60)	4.31 (0.18, 100.81)	0.363
FBXW7		Roughage (g/week)
		<50	≥50
		OR_eg (95% CI)^a		ORi (95% CI)^a	P value^b
	Del + wt	1.00	0.62 (0.41, 0.95)
	Amp	0.57 (0.22, 1.50)	0.37 (0.15, 0.91)	1.04 (0.30, 3.67)	0.946
		Fish (times/week)
		≤1	>1
		OR_eg (95% CI)^a		ORi (95% CI)^a	P value^b
	Del + wt	1.00	0.34 (0.24, 0.66)
	Amp	0.64 (0.28, 1.44)	0.25 (0.07, 0.94)	0.99 (0.20, 4.88)	0.993
		Refined grains (g/day)
		≤250	>250
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	2.28 (1.37, 3.80)
	Del + amp	0.87 (0.45, 1.67)	2.81 (1.52, 6.86)	1.43 (0.49, 4.19)	0.519
		Fat meat
		No	Yes
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	2.23 (1.35, 3.68)
	Del + amp	0.76 (0.40, 1.47)	2.30 (1.03, 5.11)	1.35 (0.47, 3.82)	0.577
		Pork (g/week)
		≤250	>250
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	1.34 (0.87, 2.06)
	Del + amp	0.46 (0.21, 0.99)	1.92 (0.90, 4.11)	3.13 (1.06, 9.41)	0.040
		Physical exercise
		No	Yes
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	0.06 (0.02, 0.20)
	Del + amp	1.58 (0.66, 3.78)	0.06 (0.01, 0.31)	0.65 (0.10, 4.47)	0.662
NEDD4-1		Refined grains (g/day)
		≤250	>250	interaction
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Del + wt	1.00	2.61 (1.61, 4.24)
	Amp	1.63 (0.56, 4.71)	2.83 (1.02, 7.88)	0.67 (0.15, 2.89)	0.587
	Wt	1.00	2.63 (1.62, 4.27)
	Del + amp	1.48 (0.57,3.86)	2.75 (1.00, 7.55)	0.71 (0.18, 2.81)	0.622
		Chinese pickled sour cabbage (times/month)
		≤2	>2
		OR_eg (95% CI)¹		OR_i (95% CI)^a	P value^b
	Del + wt	1.00	1.86 (1.21, 2.85)
	Amp	3.13 (0.92, 10.62)	3.59 (1.23, 10.48)	1.79 (0.41, 7.88)	0.444
		Fat meat
		No	Yes
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Del + wt	1.00	2.26 (1.43, 3.58)
	Amp	1.03 (0.35, 3.00)	3.60 (1.27, 10.19)	1.54 (0.35, 6.71)	0.564
	Wt	1.00	2.27 (1.43, 3.60)
	Del + amp	1.00 (0.38, 2.62)	3.30 (1.21, 9.14)	1.46 (0.37, 5.84)	0.590
		Physical exercise
		No	Yes
		OR_eg (95% CI)^a		OR_i (95% CI)^a	P value^b
	Wt	1.00	0.06 (0.02, 0.20)
	Del + amp	1.58 (0.66, 3.78)	0.06 (0.01, 0.31)	10.27 (0.60, 177.48)	0.109

^aAdjusted for gender, occupation, education, and family history of cancer. ^bP < 0.05 in the conditional logistic regression analysis was considered statistically significant. ^c leftovers: leftovers more than 12 hours.