Table 5. The relationships between gene CNVs and prognosis of CRC.
| CNV Genotypes | Total patients (n = 323) | P Valueb | Colon cancer (n = 108) | P Valuec | Rectal cancer (n = 214) | P Valuec | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients (%) | 5-Year Survival (%) | 3-Year Survival (%) | OS (Mean (SD)) (month) | HR (95% CI)a | Patients (%) | 5-year survival (%) | 3-year survival (%) | OS (Mean (SD)) (month) | HR (95% CI)a | Patients (%) | 5-year survival (%) | 3-year survival (%) | OS (Mean (SD)) (month) | HR (95% CI)a | ||||
| FBXW7 | ||||||||||||||||||
| Wt | 255 (83.6) | 59 | 68 | 74.00 (2.53) | 1.00 | 88 (85.4) | 62 | 71 | 77.32 (4.35) | 1.00 | 166 (82.5) | 58 | 68 | 72.48 (3.09) | 1 | |||
| Del | 27 (8.9) | 68 | 76 | 82.75 (7.61) | 0.62 (0.29, 1.33) | 0.220 | 10 (9.7) | 48 | 70 | 68.95 (11.96) | 1.09 (0.41, 2.88) | 0.868 | 17 (8.5) | 81 | 81 | 90.74 (9.01) | 0.31 (0.07, 1.26) | 0.100 |
| Amp | 23 (7.5) | 61 | 70 | 79.35 (8.18) | 0.91 (0.46, 1.83) | 0.793 | 5 (4.9) | 20 | 40 | 35.40 (12.23) | 3.39 (1.03, 11.18) | 0.045 | 18 (9.0) | 72 | 78 | 89.61 (7.71) | 0.48 (0.18, 1.29) | 0.146 |
| Amp v.s. del + wt | 0.95 (0.48, 1.90) | 0.888 | 3.38 (1.05, 11.12) | 0.045 | 0.51 (0.19, 1.38) | 0.185 | ||||||||||||
| Del + amp v.s. wt | 0.75 (0.44, 1.29) | 0.299 | 1.57 (0.74, 3.34) | 0.242 | 0.41 (0.18, 0.92) | 0.031 | ||||||||||||
| MDM2 | ||||||||||||||||||
| Wt | 298 (94.6) | 60 | 68 | 74.28 (2.35) | 1.00 | 99 (96.1) | 56 | 68 | 73.5 (4.18) | 1.00 | 198 (93.8) | 60 | 69 | 74.97 (2.84) | 1 | |||
| Del | 9 (2.9) | 67 | 67 | 75.22 (14.09) | 0.72 (0.23, 2.29) | 0.580 | 4 (3.9) | 75 | 75 | 81.25 (20.59) | 0.62 (0.08, 4.61) | 0.640 | 5 (2.4) | 60 | 60 | 55.40 (13.56) | 1.13 (0.27, 4.80) | 0.867 |
| Amp | 8 (2.5) | 61 | 61 | 60.60 (9.15) | 0.80 (0.25, 2.57) | 0.707 | 0 | 8 (3.8) | 61 | 61 | 60.60 (9.15) | 0.96 (0.30, 3.13) | 0.956 | |||||
| Amp v.s. del + wt | 0.81 (0.25, 2.61) | 0.727 | 0.96 (0.30, 3.11) | 0.949 | ||||||||||||||
| Del + amp v.s. wt | 0.76 (0.33, 1.75) | 0.517 | 0.62 (0.08, 4.61) | 0.640 | 1.03 (0.40, 2.61) | 0.957 | ||||||||||||
| SKP2 | ||||||||||||||||||
| Wt | 284 (95.3) | 60 | 70 | 75.34 (2.39) | 1.00 | 95 (95.0) | 58 | 69 | 74.9 (44.23) | 1.00 | 188 (95.5) | 61 | 70 | 75.79 (2.90) | 1 | |||
| Del | 6 (2.0) | 50 | 67 | 68.50 (15.37) | 1.31 (0.41, 4.17) | 0.658 | 3 (3.0) | 33 | 67 | 43.33 (16.85) | 3.62 (0.80, 16.31) | 0.094 | 3 (1.5) | 67 | 67 | 84.00 (15.51) | 0.75 (0.10, 5.55) | 0.777 |
| Amp | 8 (2.7) | 42 | 42 | 50.03 (11.55) | 1.39 (0.51, 3.79) | 0.526 | 2 (2.0) | 19.50 (3.89) | 4.68 (0.57, 38.39) | 0.151 | 6 (3.0) | 46 | 46 | 53.83 (12.53) | 0.99 (0.30, 3.22) | 0.985 | ||
| Amp v.s. del + wt | 1.38 (0.50, 3.78) | 0.531 | 4.47 (0.55, 36.48) | 0.162 | 0.99 (0.31, 3.22) | 0.990 | ||||||||||||
| Del + amp v.s. wt | 1.35 (0.62, 2.91) | 0.447 | 3.92 (1.13, 3.66) | 0.032 | 0.93 (0.33, 2.54) | 0.865 | ||||||||||||
| β-TRCP | ||||||||||||||||||
| Wt | 282 (91.0) | 58 | 68 | 74.09 (2.42) | 1.00 | 90 (89.1) | 58 | 68 | 73.97 (4.41) | 1.00 | 191 (91.8) | 59 | 68 | 74.47 (2.89) | 1 | |||
| Del | 4 (1.3) | 100 | 100 | 90.53 (11.69) | 0.962 | 3 (3.0) | 100 | 100 | 86.00 (14.69) | 0.976 | 1 (0.5) | 100 | 100 | 79 | 0.971 | |||
| Amp | 24 (7.7) | 66 | 74 | 63.25 (5.44) | 0.42 (0.19, 0.97) | 0.050 | 8 (7.9) | 50 | 75 | 61.00 (8.08) | 0.61 (0.18, 2.03) | 0.421 | 16 (7.7) | 74 | 74 | 64.01 (7.04) | 0.22 (0.06, 0.86) | 0.029 |
| Amp v.s. del + wt | 0.44 (0.19, 1.01) | 0.052 | 0.63 (0.19, 2.08) | 0.444 | 0.22 (0.06, 0.86) | 0.029 | ||||||||||||
| Del + amp v.s. wt | 0.39 (0.17, 0.88) | 0.023 | 0.50 (0.16, 1.57) | 0.230 | 0.21 (0.06, 0.83) | 0.026 | ||||||||||||
| NEDD4-1 | ||||||||||||||||||
| Wt | 269 (89.7) | 59 | 68 | 74.39 (2.46) | 1.00 | 89 (87.9) | 56 | 68 | 73.35 (4.44) | 1.00 | 181 (90.5) | 60 | 68.4 | 75.23 (2.94) | 1 | |||
| Del | 2 (0.6) | 50 | 50 | 46.00 (23.34) | 1.02 (0.14, 7.66) | 0.985 | 0 | 2 (1.0) | 50 | 50 | 46.00 (23.34) | 0.85 (0.11, 6.81) | 0.878 | |||||
| Amp | 29 (9.7) | 65 | 72 | 74.79 (7.61) | 0.82 (0.40, 1.70) | 0.597 | 12 (12.1) | 58 | 67 | 70.83 (12.27) | 1.06 (0.41, 2.76) | 0.900 | 17 (8.5) | 77 | 76 | 70.12 (8.26) | 0.73 (0.23, 2.35) | 0.595 |
| Amp v.s. del + wt | 0.82 (0.40, 1.70) | 0.597 | 1.06 (0.41, 2.76) | 0.900 | 0.73 (0.23, 2.35) | 0.595 | ||||||||||||
| Del + amp v.s. wt | 0.84 (0.42, 1.67) | 0.620 | 1.06 (0.41, 2.76) | 0.900 | 0.75 (0.27, 2.09) | 0.578 | ||||||||||||
CI, confidence interval; HR, hazard ratio; OS, overall survival.
aadjusted for CEA and CA19-9 level before surgery, Dukes stage, pathological type and metastasis. bP < 0.05 in the survival analysis was considered statistically significant. cP < 0.025 in the stratified survival analysis by location was considered statistically significant.