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. 2016 Jul 15;6:29802. doi: 10.1038/srep29802

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Copyright © 2016, Macmillan Publishers Limited

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Expression of HSP47 at the small peripheral incision or at the flap vertical incision (A), and at central corneas (B). Bar graphs showing the mean number of HSP47-positive cells at the small peripheral incision or flap vertical incision (C), and at the central corneas (D). There was a significant HSP47 up-regulation at the incision site as well as at the central cornea in the hyperopic-LASIK groups (both +2.00 D and +4.00 D) than other groups throughout the study period. At the small peripheral incision site, the SMILE +2.00 D and SMILE +4.00 D groups had significantly more HSP47 expression than the SMILE-W2D and SMILE-W4D groups at week 1. Nuclei were counterstained with DAPI (blue). Original magnification: 100X, scale bar 50 μm. Error bars represent SD. *indicates P < 0.05.