Table 5. Median survival (months) and multivariable HR for death after diagnosis of metastatic (M1) colorectal cancer, by sex, primary site, histological subtype, age at diagnosis, stage, and metastatic site.
Characteristic | N | HR | 95% CI | Median survival (months) | |
---|---|---|---|---|---|
Total | 3379 | 9 | |||
Sex | |||||
Men | 1902 | 1 | 1 | 1 | 10 |
Women | 1477 | 1.01 | 0.93 | 1.09 | 8 |
Age at diagnosis | |||||
<60 | 673 | 1 | 1 | 1 | 12 |
60–69 | 1011 | 1.09 | 0.97 | 1.23 | 11 |
70–79 | 1007 | 1.60 | 1.43 | 1.80 | 8 |
>79 | 688 | 2.40 | 2.12 | 2.72 | 5 |
T stage | |||||
T1 | 35 | 1.38 | 0.91 | 2.11 | 10 |
T2 | 90 | 0.63 | 0.47 | 0.85 | 16.5 |
T3 | 1331 | 1 | 1 | 1 | 13 |
T4 | 933 | 1.53 | 1.39 | 1.70 | 8 |
TX | 930 | 2.07 | 1.77 | 2.42 | 5 |
N stage | |||||
N0 | 476 | 1 | 1 | 1 | 19 |
N1 | 710 | 1.52 | 1.31 | 1.77 | 13 |
N2 | 1113 | 2.09 | 1.82 | 2.40 | 8 |
NX | 1080 | 2.23 | 1.87 | 2.65 | 5 |
Metastatic site | |||||
Thorax | 220 | 0.64 | 0.55 | 0.76 | 14 |
Peritoneum | 271 | 0.81 | 0.70 | 0.95 | 7 |
Liver | 2643 | 1 | 1 | 1 | 9 |
Gastro-intestinal | 48 | 0.72 | 0.53 | 0.99 | 6.5 |
Bone | 42 | 1.56 | 1.13 | 2.16 | 5.5 |
Nervous system | 32 | 1.73 | 1.21 | 2.49 | 4 |
Other | 123 | 0.87 | 0.71 | 1.07 | 9 |
Anatomical site | |||||
Proximal colon | 1051 | 1.42 | 1.29 | 1.56 | 6 |
Distal colon | 1202 | 0.96 | 0.87 | 1.07 | 11 |
Rectum | 1126 | 1 | 1 | 1 | 11 |
Histological subtype | |||||
Adenocarcinoma | 3153 | 1 | 1 | 1 | 9 |
Signet ring/Mucinous | 226 | 0.83 | 0.70 | 0.98 | 10 |
Only patients with one distant metastasis are included.
Bold values indicate significantly higher hazard, and underlined values indicate significantly lower hazard.