Table 5. Median survival (months) and multivariable HR for death after diagnosis of metastatic (M1) colorectal cancer, by sex, primary site, histological subtype, age at diagnosis, stage, and metastatic site.
| Characteristic | N | HR | 95% CI | Median survival (months) | |
|---|---|---|---|---|---|
| Total | 3379 | 9 | |||
| Sex | |||||
| Men | 1902 | 1 | 1 | 1 | 10 |
| Women | 1477 | 1.01 | 0.93 | 1.09 | 8 |
| Age at diagnosis | |||||
| <60 | 673 | 1 | 1 | 1 | 12 |
| 60–69 | 1011 | 1.09 | 0.97 | 1.23 | 11 |
| 70–79 | 1007 | 1.60 | 1.43 | 1.80 | 8 |
| >79 | 688 | 2.40 | 2.12 | 2.72 | 5 |
| T stage | |||||
| T1 | 35 | 1.38 | 0.91 | 2.11 | 10 |
| T2 | 90 | 0.63 | 0.47 | 0.85 | 16.5 |
| T3 | 1331 | 1 | 1 | 1 | 13 |
| T4 | 933 | 1.53 | 1.39 | 1.70 | 8 |
| TX | 930 | 2.07 | 1.77 | 2.42 | 5 |
| N stage | |||||
| N0 | 476 | 1 | 1 | 1 | 19 |
| N1 | 710 | 1.52 | 1.31 | 1.77 | 13 |
| N2 | 1113 | 2.09 | 1.82 | 2.40 | 8 |
| NX | 1080 | 2.23 | 1.87 | 2.65 | 5 |
| Metastatic site | |||||
| Thorax | 220 | 0.64 | 0.55 | 0.76 | 14 |
| Peritoneum | 271 | 0.81 | 0.70 | 0.95 | 7 |
| Liver | 2643 | 1 | 1 | 1 | 9 |
| Gastro-intestinal | 48 | 0.72 | 0.53 | 0.99 | 6.5 |
| Bone | 42 | 1.56 | 1.13 | 2.16 | 5.5 |
| Nervous system | 32 | 1.73 | 1.21 | 2.49 | 4 |
| Other | 123 | 0.87 | 0.71 | 1.07 | 9 |
| Anatomical site | |||||
| Proximal colon | 1051 | 1.42 | 1.29 | 1.56 | 6 |
| Distal colon | 1202 | 0.96 | 0.87 | 1.07 | 11 |
| Rectum | 1126 | 1 | 1 | 1 | 11 |
| Histological subtype | |||||
| Adenocarcinoma | 3153 | 1 | 1 | 1 | 9 |
| Signet ring/Mucinous | 226 | 0.83 | 0.70 | 0.98 | 10 |
Only patients with one distant metastasis are included.
Bold values indicate significantly higher hazard, and underlined values indicate significantly lower hazard.