Table 3. Pooled estimates of diagnostic indexes regarding the accuracy of autofluorescence for the PML and ML of the oral cavity, lung, esophagus, stomach, and colorectum.
| Test | No. of studies | No. of samples | sensitivity | Pooled estimates (95% CI) | ||||
|---|---|---|---|---|---|---|---|---|
| specificity | PLR | NLR | DOR | AUC | ||||
| Oral cavity | 24 | 2761 | 0.89 (0.82–0.93) | 0.80 (0.64–0.90) | 4.54 (2.28–9.04) | 0.14 (0.08–0.24) | 32.37 (10.47–100.12) | 0.92 (0.89–0.94) |
| Lung | 25 | 4384 | 0.89 (0.86–0.92) | 0.63 (0.52–0.73) | 2.43 (1.82–3.24) | 0.17 (0.13–0.22) | 14.52 (9.25–22.81) | 0.89 (0.86–0.91) |
| Esophagus | 12 | 2514 | 0.78 (0.57–0.91) | 0.77 (0.58–0.89) | 3.43 (1.81–6.50) | 0.28 (0.14–0.58) | 12.17 (4.32–34.27) | 0.85 (0.81–0.87) |
| Stomach | 9 | 2115 | 0.88 (0.76–0.94) | 0.73 (0.50–0.88) | 3.28 (1.52–7.08) | 0.17 (0.07–0.39) | 19.31 (4.49–83.05) | 0.89 (0.86–0.92) |
| Colorectum | 19 | 2904 | 0.91 (0.86–0.94) | 0.78 (0.64–0.88) | 4.15 (2.40–7.17) | 0.11 (0.07–0.19) | 36.27 (14.20–92.63) | 0.93 (0.91–0.95) |
PML: premalignant lesions; ML: malignant lesions; CI: confidence interval; PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odd ratio; AUC: area under the curve.