Table 4. Pooled estimates of diagnostic indexes regarding the accuracy of using autofluorescence alone or with algorithms for detecting OSCC and OPMD.
| Test | No. of studies | No. of samples | sensitivity | Pooled estimates (95%CI) |
||||
|---|---|---|---|---|---|---|---|---|
| specificity | PLR | NLR | DOR | AUC | ||||
| (A) AF only | 16 | 1693 | 0.88 (0.77–0.94) | 0.62 (0.41–0.79) | 2.31 (1.31–4.09) | 0.20 (0.09–0.46) | 11.52 (3.10–42.87) | 0.85 (0.82–0.88) |
| (B) AF with algorithms | 8 | 1068 | 0.92 (0.88–0.94) | 0.95 (0.92–0.97) | 17.28 (10.96–27.22) | 0.09 (0.06–0.13) | 194.11 (94.27–399.71) | 0.98 (0.96–0.99) |
| u test of A and B (p value) | — | — | NS | * | * | NS | * | * |
OSCC: oral squamous cell carcinoma; OPMD: oral potentially malignant disorders; CI: confidence interval; PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odd ratio; AUC: area under the curve; AF: autofluorescence;
NS: non-significant (p > 0.05); *p < 0.05.