Table 5.
Generalized Estimating Equation Logistic Regression on Recurrent Malaria by Day 28
| Variables | Recurrent Malaria by Day 28 |
|||||
|---|---|---|---|---|---|---|
| Unadjusted OR (95% CI) | P Value | Adjusted OR Without LR Day 7 (95% CI) | P Value | Adjusted OR With LR Day 7 (95% CI) | P Value | |
| LPV/r | Reference | |||||
| EFV | 3.38 (1.01–11.35) | .049 | 3.74 (1.02–13.74) | .04 | 1.77 (.36–8.81) | .48 |
| NVP | 2.68 (.84–8.56) | .10 | 2.86 (.85–9.60) | .09 | 2.26 (.64–8.05) | .21 |
| HIV-uninfected | 6.32 (2.23–17.95) | .0005 | 6.48 (2.18–19.21) | .0008 | 5.03 (1.58–15.98) | .006 |
| NVP | Reference | |||||
| EFV | 1.26 (.5–3.17) | .62 | 1.31 (.49–3.51) | .59 | 0.78 (.32–2.37) | .66 |
| HIV-uninfected | 2.36 (1.21–4.58) | .01 | 2.27 (1.12–4.60) | .02 | 2.22 (1.10–4.48) | .03 |
| EFV | Reference | |||||
| HIV-uninfected | 1.87 (.86–4.06) | .11 | 1.73 (.73–4.11) | .21 | 2.84 (1.04–7.78) | .04 |
| Parasite density at baseline, log | 1.12 (1.01–1.24) | .03 | 1.04 (.92–1.18) | .53 | 1.03 (.91–1.18) | .61 |
| Hb at baseline, g/dL | 0.82 (.69–.97) | .02 | 0.82 (.68–1.00) | .05 | 0.82 (.67–.99) | .04 |
| Age, y | 0.81 (.7–.95) | .008 | 0.90 (.76–1.07) | .22 | 0.92 (.77–1.10) | .36 |
| LR level at day 7 in ng/mLa | 0.73 (.58–.92) | .008 | 0.75 (.58–.96) | .02 | ||
| LR day 7 ≥ 200 ng/mL | 0.56 (.34–.92) | .02 | ||||
| LR day 7 ≥ 175 ng/mL | 0.57 (.33–.97) | .04 | ||||
| LR day 7 ≥ 280 ng/mL | 0.65 (.41–1.02) | .06 | ||||
Abbreviations: CI, confidence interval; EFV, efavirenz; Hb, hemoglobin; HIV, human immunodeficiency virus; LPV/r, lopinavir/ritonavir; LR, lumefantrine; NVP, nevirapine; OR, odds ratio.
a Natural log-transformed lumefantrine concentration on day 7.