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. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: Prostate. 2016 Apr 4;76(11):964–976. doi: 10.1002/pros.23185

Micturition, conscious cystometry monitoring and bladder histology and proliferation in C57BL/6N and B6.V-Lepob/J mice between 12–28 weeks. A, typical voiding events at 24 h, B, representative conscious cystometrogram, and C, number of voiding events in 24 h. D-a, representative image of H&E staining of the whole bladder at 28 weeks. D-b, representative image of IHC staining of PCNA in the bladder urothelium at 28 weeks. A significant difference in micturition and voiding events were noted between the groups. Bladder of B6.V-Lepob/J mice, compared to C57BL/6N mice is slightly thicker and appears more proliferative along with scattered urothelial cells containing pigment granules, most likely lecithin (dark brown in color), as shown by arrows. Values represent Mean ± SEM, *p<0.05, **p<0.001, compared to C57BL/6 mice. Representative H&E and IHC staining photomicrograph of the mouse bladder (×100, and ×400 magnification). Details are described in ‘materials and methods’ section.

Micturition, conscious cystometry monitoring and bladder histology and proliferation in C57BL/6N and B6.V-Lepob/J mice between 12–28 weeks. A, typical voiding events at 24 h, B, representative conscious cystometrogram, and C, number of voiding events in 24 h. D-a, representative image of H&E staining of the whole bladder at 28 weeks. D-b, representative image of IHC staining of PCNA in the bladder urothelium at 28 weeks. A significant difference in micturition and voiding events were noted between the groups. Bladder of B6.V-Lepob/J mice, compared to C57BL/6N mice is slightly thicker and appears more proliferative along with scattered urothelial cells containing pigment granules, most likely lecithin (dark brown in color), as shown by arrows. Values represent Mean ± SEM, *p<0.05, **p<0.001, compared to C57BL/6 mice. Representative H&E and IHC staining photomicrograph of the mouse bladder (×100, and ×400 magnification). Details are described in ‘materials and methods’ section.