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. 2016 Jan 13;41(9):2192–2205. doi: 10.1038/npp.2015.351

Figure 2.

Figure 2

Deletion of CB1 on GABAergic, but not on cortical glutamatergic neurons, increases the primary reinforcing effects of cocaine and cocaine-induced extracellular DA in the NAc. (a) Cocaine self-infusions as a function of dose for intravenous self-administration at fixed ratio 2 schedule (FR2) in Glu-CB1-KO mice (n=7) and Glu-CB1-WT (n=15). (b) Cocaine self-infusions as a function of dose for intravenous self-administration in a progressive ratio schedule (PR) in Glu-CB1-KO (n=7) and Glu-CB1-WT (n=15). (c) Same as (a) in GABA-CB1-KO (n=10) and GABA-CB1-WT (n=12). (d) Same as (b) in GABA-CB1-KO (n=10) and GABA-CB1-WT (n=12). (e) Extracellular DA concentration measured in the NAc by microdialysis in response to vehicle (Veh) and to cocaine 20 mg/kg (Coc) in freely moving Glu-CB1-KO (n=4–6 per condition) and Glu-CB1-WT (n=4–6 per condition). (f) Same as (e) in GABA-CB1-KO and GABA-CB1-WT. Data are expressed as mean±SEM.