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. 2016 Feb 24;41(9):2224–2231. doi: 10.1038/npp.2016.14

Figure 3.

Figure 3

The effect of glutamic acid decarboxylase 1 (GAD1) rs3749034 genotype on long-interval cortical inhibition (LICI) cluster size in healthy control (n=33) and patients with schizophrenia (n=23) undergoing transcranial magnetic stimulation with electroencephalography (TMS-EEG) stimulation to the dorsolateral prefrontal cortex (DLPFC). Blue and red represent healthy controls and schizophrenia patients, respectively. Hollow circles represent each subject with C-allele homozygotes and solid circles represent each carriers of the T allele. Mean and 95% confidence intervals for each group are to the immediate right. DLPFC LICI cluster size has been log transformed and corrected for age (35.5 years). There is significant genotype-by-diagnosis interaction (F1,56=14.3, P=4.1 × 10−4). Healthy control C-allele homozygotes (n=20; mean: 4.56±0.52) have lower DLPFC LICI cluster size than T-allele carriers (n=13; mean±SD: 5.08±0.30; F1,33=10.1, P=0.003). Schizophrenia patients that are C-allele homozygotes (n=10, 4.94±0.34) have higher DLPFC LICI cluster size than T-allele carriers (n=13, 4.51±0.53; F1,23=4.8, P=0.4). CNT, healthy control; SCZ, patients with schizophrenia; SD, standard deviation.